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Sunday, February 3, 2013

Omega 3 and Coenzyme Q-10 Supplements Decrease PSA (prostatic-specific antigen) Levels

A recently published study showed that both omega 3 fats and Coenzyme Q10 may help prostate health.  In the study, 504 healthy men aged 40 to 70 with prostate-specific antigen (10) levels < 2•5 nanograms/milliliter were given one of the following per day for 12 weeks:
  • Omega-3 fatty acids (4.48 grams of EPA and 2.88 grams of DHA = 126 patients)
  • Omega-6 fatty acids (2,400 milligrams of Gamma-linolenic acid = 126 patients)
  • CoQ10 (400 milligrams = 126 patients)
  • Placebo = 126 patients

By the end of 12 weeks, those in the EPA/DHA group saw their prostate-specific antigen levels significantly fall by 30% .  This compared to a 15% increase in the gamma-linolenic acid group and a 33% drop in the Coenzyme Q10.

No data is available for a EPA/DHA+ COnezyme Q10 combination.

 2012 Nov 30:1-8. [Epub ahead of print]

Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial.


Clinical Center for Urological Disease Diagnosis and Private Clinic Specialized in Urological and Andrological Genetics, PO Box 19395-1849, Tehran, Iran.


The main objective of the present study was to determine the potential of n-3 and n-6 fatty acids or coenzyme Q10 (CoQ10) to alter serum prostate-specific antigen (PSA) levels in normal healthy men. A total of 504 healthy men with serum PSA level ≤ 2·5 ng/ml were recruited into the study. Serum PSA values were not segregated by decade of age. Participants were randomly assigned to a daily dietary supplement containing n-3 fatty acids (1·12 g of EPA and 0·72 g of DHA per capsule) (group 1, n 126), n-6 fatty acid (600 mg γ-linolenic acid (GLA) each capsule) (group 2, n 126), CoQ10 (100 mg per capsule) (group 3, n 126) or a similar regimen of placebo (group 4, n 126) for 12 weeks. Study medication was administered as two capsules to be taken twice daily. Serum levels of PSA, EPA, DHA, GLA, lipid profile and reproductive hormones were also measured. EPA treatment significantly reduced serum PSA level by 30·0 (95 % CI 25, 36) % (P = 0·004) from baseline. In contrast, GLA therapy significantly increased serum PSA concentration by 15·0 (95 % CI 11, 20) % (P = 0·02). CoQ10 therapy also significantly reduced serum PSA level by 33·0 (95 % CI 27, 40) % (P = 0·002). In multivariable analysis, serum values of PSA were strongly correlated with duration of EPA (r - 0·62; 95 % CI - 0·42, - 0·77; P = 0·003), n-6 (r 0·42; 95 % CI 0·31, 0·58; P = 0·02) and CoQ10 use (r - 0·77; 95 % CI - 0·56, - 0·87; P = 0·001). There were also significant correlations between serum values of DHA, EPA, GLA and CoQ10 and serum PSA levels. The present study demonstrates that dietary supplements containing EPA, GLA or CoQ10 may significantly affect serum PSA levels.

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