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Showing posts with label supplements. Show all posts
Showing posts with label supplements. Show all posts

Wednesday, April 10, 2013

Another Company is Caught Adding an Analog of Viagra to Its "Natural" Testosterone Booster Supplement






Consumer Concepts, Inc. notified the public of a consumer/user level recall of all ROCK-It MAN Male Enhancement Capsules sold between October, 2012 and April, 2013. Analytical tests conducted by the FDA concluded that the product contained hydroxythiohomosildenafil. 

Hydroxythiohomosildenafil is an analogue of sildenafil (Viagra) and is expected to possess a similar pharmacological and adverse event profile. Sildenafil is the active pharmaceutical ingredient in a FDA approved drug that is used to treat erectile dysfunction, making these products unapproved new drugs.

http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm347125.htm?source=govdelivery

Monday, April 8, 2013

Media Sensationalism: Meat and Carnitine are Bad for your Heart



This study was recently published, pushing the hypothesis that L-Carnitine in meats could be a connection between meats and cardiovascular disease risk, via TMAO (Trimethylamine oxide). It has received a lot of media coverage today. But there is a lot of speculation in this study.

For more click here

Carnitine and Heart Disease- Positive Results

8.1. Blood Pressure

ALCAR in conjunction with ALA can potentially reduce hypertension in via their combined anti-oxidant and pro-energetic effects[165] as well as insulin resistance and glucose tolerance in those with compromised cardiac health[166] with minimal to no side-effects at the dosage of 2g a day. At this dose of 2g daily, it has been implicating in reducing blood pressure in persons with poor glucose tolerance by almost 10 points systolic, with some decrease in diastolic as well.[49]
A dose of 4.5g GPLC has been shown to increase nitric oxide levels after 28 days of supplementation in some persons,[1] and does so at a dose of 3g as well.[33]
 May benefit blood pressure in unhealthy persons (metabolic syndrome, high blood pressure). Has the mechanisms to improve blood pressure independent of a disease state via nitric oxide, but it is unclear how it affects blood pressure in those with normal blood pressure.

8.2. Disorders of Blood Flow

Carnitine, in the form of Propionyl-L-Carnitine (PLC, or GPLC if bound to Glycine), has been shown to improve symptoms of intermittent claudication. PLC supplementation at a dose of 1-3g a day seems to reliably increase maximum walking time in persons suffering from intermittent claudication[14][167][15] and improve quality of life.[13] The benefit does not appear to be dose dependent, and seems to benefit persons with more severe symptoms to a greater degree than persons with lesser symptoms.
PLC aids peripheral arterial diseases in general as it increases peripheral microcirculation.[168][169] In persons with peripheral arterial diseases, PLC supplementation can increase strength and exercise performance[170] although exercise itself can also be seen as therapeutic.[171]
 Quite promising for periphery artery disease and intermittent claudication

8.3. Aging

During aging, defects in oxidative phosphorylation occur exclusively in Interfibrillar mitochondria, located between myofibrils.[172][173] Due to substrate poorly oxidized when introduced into complexes I, III, and IV and not alleviated by uncoupling it appears the aging 'defect' associated with cardiac mitochondria is located in the Electron Transport Chain.[113]Enzymatic activity of complexes III (through cytochrome C binding) and IV also appear to be decreased during cardiac aging.[172][174][175]
It appears these damages may be secondary to cardiac Ischemia.[113] Ischemia causes damage to the Electron Transport Chain after 10-20 minutes via reducing activity of complex I[176] and reducing phosphorylation at complex V and adenine dinucleotide translocase.[177][178] Complex III[176] and IV[179] are hindered at longer periods of Ischemia. It appears that the general process of Ischemia hits elderly persons harder than youth[180] despite some level of damage at both ages.[181]
Acetyl-L-Carnitine is proposed to target these defects its various mitochondrial benefits, discussed elsewhere. One such benefit is seen when aged rats were given a bolus of Acetyl-L-Carnitine 3 hours before cardiac Ischemia, and suffered less damage.[182] The same benefits were not seen with adult hearts subject to Ischemia, and the damage induced to aged hearts defaulted to similar levels as adult hearts.[182][113]
Another possible mechanism is increasing levels of CPT1 in the myocardium, without affecting overall carnitine levels.[183] A decline of this rate-limiting step is seen during aging, thus upregulating it may attenuate changes seen with aging. It has been noted in human hearts that less fatty acid oxidation occurs with aging, causing a shift towards cardiac glucose metabolism[184]which are thought to be due to less CPT1 activity.[185][186]

Sunday, February 3, 2013

Omega 3 and Coenzyme Q-10 Supplements Decrease PSA (prostatic-specific antigen) Levels





A recently published study showed that both omega 3 fats and Coenzyme Q10 may help prostate health.  In the study, 504 healthy men aged 40 to 70 with prostate-specific antigen (10) levels < 2•5 nanograms/milliliter were given one of the following per day for 12 weeks:
  • Omega-3 fatty acids (4.48 grams of EPA and 2.88 grams of DHA = 126 patients)
  • Omega-6 fatty acids (2,400 milligrams of Gamma-linolenic acid = 126 patients)
  • CoQ10 (400 milligrams = 126 patients)
  • Placebo = 126 patients

By the end of 12 weeks, those in the EPA/DHA group saw their prostate-specific antigen levels significantly fall by 30% .  This compared to a 15% increase in the gamma-linolenic acid group and a 33% drop in the Coenzyme Q10.

No data is available for a EPA/DHA+ COnezyme Q10 combination.



Reference:
 2012 Nov 30:1-8. [Epub ahead of print]

Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial.

Source

Clinical Center for Urological Disease Diagnosis and Private Clinic Specialized in Urological and Andrological Genetics, PO Box 19395-1849, Tehran, Iran.

Abstract

The main objective of the present study was to determine the potential of n-3 and n-6 fatty acids or coenzyme Q10 (CoQ10) to alter serum prostate-specific antigen (PSA) levels in normal healthy men. A total of 504 healthy men with serum PSA level ≤ 2·5 ng/ml were recruited into the study. Serum PSA values were not segregated by decade of age. Participants were randomly assigned to a daily dietary supplement containing n-3 fatty acids (1·12 g of EPA and 0·72 g of DHA per capsule) (group 1, n 126), n-6 fatty acid (600 mg γ-linolenic acid (GLA) each capsule) (group 2, n 126), CoQ10 (100 mg per capsule) (group 3, n 126) or a similar regimen of placebo (group 4, n 126) for 12 weeks. Study medication was administered as two capsules to be taken twice daily. Serum levels of PSA, EPA, DHA, GLA, lipid profile and reproductive hormones were also measured. EPA treatment significantly reduced serum PSA level by 30·0 (95 % CI 25, 36) % (P = 0·004) from baseline. In contrast, GLA therapy significantly increased serum PSA concentration by 15·0 (95 % CI 11, 20) % (P = 0·02). CoQ10 therapy also significantly reduced serum PSA level by 33·0 (95 % CI 27, 40) % (P = 0·002). In multivariable analysis, serum values of PSA were strongly correlated with duration of EPA (r - 0·62; 95 % CI - 0·42, - 0·77; P = 0·003), n-6 (r 0·42; 95 % CI 0·31, 0·58; P = 0·02) and CoQ10 use (r - 0·77; 95 % CI - 0·56, - 0·87; P = 0·001). There were also significant correlations between serum values of DHA, EPA, GLA and CoQ10 and serum PSA levels. The present study demonstrates that dietary supplements containing EPA, GLA or CoQ10 may significantly affect serum PSA levels.

Wednesday, December 12, 2012

Nelson's Tips and Suggested Supplements


Here are some tips and suggestions :


Supplements:

Zinc/Copper: One, twice a day with food (this supports healthy testosterone and low chances for acne): http://www.amazon.com/Jarrow-Zinc-Balance-100-caps/dp/B001602A10/ref=sr_1_2?ie=UTF8&s=hpc&qid=1302649942&sr=8-2


Carnitine, 1000 mg with breakfast and 1000 mg with lunch:


Vitamin D (4000 IU per day): 

Coenzyme Q-10 (200 mg per day):


Whey Protein (1 or 2 servings a day, no need for a blender- This is the most tolerable and light of all)

Creatine (5 grams per day, two hours before exercise- NOT for people with kidney dysfunction)



Pill box:



For studies and references on each supplement, visit:

  http://examine.com/supplements/




Tuesday, November 6, 2012

How to Maximize Your Health - Practical Tips For Men and Women



By Nelson Vergel

From the book: Testosterone: A Man's Guide (available on amazon)

These are practical tips that anyone can start adding to their lives.  Most have been proven to work by different scientific studies.

  • Exercise with weights/machines three to four times a week for no more than one hour; this helps build muscle. On alternate days do cardiovascular exercise (elliptical trainer, fast walking, light jogging, etc.) for at least 30 minutes a day; this helps with stamina and overall health. Make sure that you sweat! Discuss your exercise program with your doctor before you start.
  • At the start of any exercise program and every three months measure your chest, thighs, arms, and abdomen. Weigh yourself weekly.
  • It is not a bad idea if you are over 40 to ask your doctor for a full body DEXA (dual X Ray Absorptiometry) scan so that you can know how many grams of muscle, fat and bone you have in every part of your body, and then repeat every three years to monitor changes. 
  • Sometimes it is difficult to find a radiology clinic that does full body DEXAs since they are usually accustomed to doing only DEXA's of the hips or spine area for post menopausal women with bone loss.
  • Take at least a multivitamin a day with meals. I like the Energy Pack from Super Nutrition.
  • Motivate yourself with a buddy or support system. I don't mean just for exercise either; surround yourself with some wise and up-beat people.
  • If you have to use stimulants, such as coffee and green tea, use them only in moderation.
  • Get good quality sleep. Talk with your doctor if you're not getting it.
  • Manage stress with relaxation techniques and hobbies. Learn to let go of anger and unrealistic expectations.
  • Get at least 20 minutes a day of sunshine (avoid the face, though). Your body needs it to make vitamin D for bone health. Get your vitamin D blood levels checked and supplement at with at least 2000 IU per day if found to have low blood levels (ask your doctor about this test).
  • Sweat. Use a pedometer to try to walk at least 10,000 steps a day. Increase your cardio by parking far away, taking the stairs, walking the dog, or dancing. Make it fun!
  • Choose your supplements wisely. Beware of companies claiming that their "growth hormone precursors" work; they don't. Most weight loss supplements have stimulants that can affect mood and increase blood pressure and cardiovascular risks.
  • Treat depression quickly with exercise, therapy, antidepressants, and a good support system
  • Get a Pneumovax vaccine every five years. Pneumovax is a vaccine against bacterial pneumonia.
  • If you've never had hepatitis A or B, ask your doctor about getting vaccinated against them.

How to Protect Your Heart

  • Do not smoke!
  • Manage stress and keep your blood pressure in check.
  • Decrease high triglycerides with Omega 3 fatty acids (cold water fish oils) and by cutting down on sugars. The American Heart Association (AHA) recommends at least two 3 oz servings of fish per week. Some experts recommend eating four 3-ounce servings of fatty fish per week for people with heart disease or cardiac risk factors. The following have higher levels of omega-3 fatty acids:
    • Anchovies
    • Bluefish
    • Carp
    • Catfish
    • Halibut
    • Herring
    • Lake trout
    • Mackerel
    • Pompano
    • Salmon
    • Tuna


  • Improve fat utilization with 2 to 4 grams a day of L-Carnitine (prescription Carnitor).
  • Increase your HDL (the good cholesterol) if it's low with Niacin 5500-1500 per day. Start with lower dose to minimize "flushing" and take an aspirin 20 min before (Niaspan is the prescription grade)
  • Maximize soluble fiber (see below).
  • If everything else fails to lower your cholesterol and triglycerides, use prescription lipid lowering agents (statins, fibrates, etc).
  • If you take lipid lowering drugs, don't forget to take 300 mg a day of Coenzyme Q10 since it has been shown to be low in those taking those medications. This supplement can protect the heart and muscle tissue from damage.
  • Take an 81mg baby aspirin a day (with your doctor's approval).

Nutritional Tips:


  • Shop mostly in the outer part of the grocery store where the fresh produce, meats, and milk products/eggs are.
  • Do not skip breakfast (keep an eye on sugar and refined flour products!)
  • Try to eat several smaller meals or snacks instead of two to three large ones.
  • Eat more almonds, walnuts, pecans and pistachios (good cholesterol lowering fats).
  • Eat fruits and vegetables of all colors.
  • Avoid sodas, sweet drinks and fruits juices (fruit sounds healthy but the juice part brings in too many sugars).
  • Drink lots of water.
  • Eat a high protein, complex carbohydrate- rich meal after work outs.
  • Minimize caffeine (it reduces appetite but can increase anxiety).
  • Get a slow cooker so that you come back from work to a warm meal.
  • Cook for the week and freeze in individual serving sized containers.
  • Reduce saturated (animal) fats, fried foods and hydrogenated oils.
  • Use good fats: olive oil, nuts, avocados, flaxseed.
  • Minimize sugars like fructose (sweets, sodas, and many processed foods are high in fructose corn syrup).
  • Eat adequate amounts (0.7-1 gm/lb/day) of protein (fish, eggs, cottage cheese, lean meats, chicken, whey, yogurt, nuts, etc).
  • Eat more high-fiber, nutrient and fluid-rich, low calorie, low glycemic carbs like: Oatmeal, multi-grain breads, vegetables, fruits, roots, greens, wild rice and beans.
  • Grocery shopping list:
    • Almonds and other nuts
    • Beans and other legumes
    • Spinach and other green leafy vegetables
    • Low fat dairy, yogurt (Greek style)
    • Hummus
    • Whey protein (I like the Isopure brand since it does not give me gut problems and it is very light)
    • Oatmeal (not the little packets; those are loaded with sugars)
    • Eggs (free range or Omega 3 enriched if possible)
    • Lean meats
    • Whole grain breads and pasta
    • Peanut, almond, cashew butters
    • Olive oil and avocados
    • Raspberries and all berries. Whole fruits (remember, not juices)
    • Occasional glass of red wine per day (optional)
    • Flaxseed, pumpkin and sunflower seeds
    • Sweet potatoes and wild rice
    • Green tea
More on healthy eating:click here

General Exercise Suggestions:

There is controversy in the literature about the effects of exercise on testosterone blood levels. Conflicting results may be explained by differences in the intensity and duration of the activity and the physical characteristics of the individual (e.g. age and fitness level).
Relatively short duration intense activity may lead to transient increases in testosterone concentrations. Athletes who train intensively may experience reductions in testosterone levels but not below normal clinical range. This is not necessarily a consistent phenomenon.
The important thing to remember is that when done correctly, exercise can have the following proven benefits that go beyond just looking good:


  • Improved muscle function and strength.
  • Reduced trunk (belly) fat
  • Increased muscle mass
  • Decreased LDL (bad cholesterol).
  • Decreased triglycerides. Muscle hypertrophy (enlargement) induced by resistance training, may decrease triglycerides in those with high levels.
  • Improved mood and decreased stress.
  • Increase bone density in men and women.
  • Improved aerobic function and lung capacity.

Getting Started

There are some things to consider before you start an exercise program.. Get your blood pressure, heart rate, weight, body dimensions, fasting cholesterol, triglycerides, and blood sugar measured. Your doctor should be able to advise you if you are capable of exercising without health risks.
If you feel too tired and weak, start by walking every day to your best ability. Walking can increase your energy levels so you can start a more intensive exercise program as you feel better. Use a cheap pedometer to measure your daily steps; try to reach 10,000 steps a day since that amount has been associated with good cardiovascular health and fat loss.
There are two types of exercise: resistance (weight) training and cardiovascular (aerobic) exercise. Resistance training uses weights to induce muscle growth. Cardiovascular exercise improves your body's aerobic capacity (the way it uses oxygen). It also increases your metabolism so that you can burn fat, lower your bad cholesterol and triglycerides, and lower your blood sugar.
Do low-impact aerobic exercise for 20-40 minutes, three to four times a week. Exercises like walking fast, bike riding (stationary or the two-wheeler), stair stepping, and using an elliptical trainer or treadmill are all effective. Switching between different exercises can help keep your interest going. Be careful about aerobic exercise if you are losing weight involuntarily, if you are overly tired or recovering from illness.

Recommendations

Train with weights and machines three times a week for no more than one hour. Starting with machines is the safest way until you get familiar with the exercises. As you feel more confident and strong, bring in free weight exercise (hopefully with the help of a workout buddy). As you get stronger, increase your weights in every exercise. Exercise one body part per week, and do three exercises per body part. One light warm-up set and two heavier sets of eight to ten repetitions to momentary muscle failure (until you cannot do another rep) are enough for each exercise. If you do not have access to a gym, do push-ups on the floor and squats holding books or large bottles full of water at home. As long as you are "resisting" your own body weight, you are doing resistance exercise. You can also get an exercise ball and follow this great home-based workout.


Important Things to Remember


  • Learn how to do each exercise correctly. Concentrate on using strict form to get the most out of each exercise and to prevent injuries.
  • Make sure your muscles are warm before targeting them with more challenging weights. Warm them up with a light, high-repetition exercise set.
  • Don't use your body to add momentum; cheating this way takes work away from the targeted muscles. Use a deliberate speed to increase the effectiveness of the movement.
  • Use a full range of motion on all exercises. Feel the muscle stretch at the bottom and go for a momentary peak contraction at the top. Don't go too fast!
  • Warm up before you work out and stretch afterwards to prevent injury. Briefly stretch the major muscle groups before your training. This helps flexibility and muscle recovery.
  • Feel the muscles working by keeping your head in what you're doing. Focus on your muscles contracting and relaxing. Concentrate on your body exercising, not on random thoughts or people around you.
  • If the weight is too light (more than 12 repetitions), try using a heavier one or do the movement more slowly and really feel the contraction. You should be barely able to finish the tenth rep if your weight is the right one. Of course, as you get stronger with time, increase your weights.
  • Keep rest periods to no more than about 20-30 seconds, or shorter, depending on how tired you are from your last set. This will also help to give your heart a mini-workout.

Safety First

Always remember -- safety first! If something you do in an exercise hurts, stop! Ask for help to figure out what you're doing wrong. Maybe it's improper form. If you hurt yourself, you will hinder your progress because you won't want to work out. Learn proper form! Do not exercise if you feel you are coming down with a cold.

Commit Yourself

If you can afford it, join a gym. If you spend the money, you'll be more likely to stay with it, and consistency is the key to success in any exercise program. Also, try to find someone who is enthusiastic to train with, or get a personal trainer (if you can afford one). It's easier to stay motivated when you train with someone else who has a vital interest in your mutual success. It's also safer to have someone to spot you when you lift heavy weight.

Avoid Overtraining

Working out for more than an hour can cause overtraining which can destroy your muscles and decrease your strength. Overtraining is probably the factor most ignored by exercise enthusiasts.Prolonged exercise (overtraining) may lead to suppression of testosterone levels, possibly lasting up to several days.

In order to build muscle the body has to receive a stimulus, a reason, to grow bigger (hypertrophy). It's really very simple: the body only does what it needs to do, what it is required to do. It isn't going to suddenly expand its muscle mass because it anticipates needing more muscles. But if it is challenged to move weights around, it will respond by growing.

Another way to look at it is, if you take any bodybuilder and put him in bed for weeks at a time, he'll begin to rapidly lose muscle mass because the body will sense that it doesn't need the extra muscle any more. By lifting weights one delivers the needed stimulus to begin muscular hypertrophy.

However, overdoing exercise stresses out the body and actually initiates the process of breaking down muscle mass as the body begins to burn its own muscles to use for fuel. This overtraining is why so many people don't grow at a satisfying rate. Even worse, these same people often will think they aren't training hard enough. They increase their exercise routines, thinking they just need more stimuli! And this is where the biggest error is made -- more is not necessarily better! It seems paradoxical that you could work out less and grow more, but this is very often the case.

Any exercise beyond that which is the exact amount of stimulus necessary to induce optimal muscle growth is called overtraining. I know this sounds non-specific but the idea is that it will vary from person to person. You need to listen to your body.

A Workout Log Is Recommended

The best reason to keep track of your workouts is so that you can see graphically what you are accomplishing. You will be able to see whether you're gaining strength at a reasonable rate. You can also analyze your pattern to see if you're overtraining. You will find when you log your workouts, that if you are overtraining, you won't be gaining in strength or muscle size. Document your workouts by keeping track of the weight you lift and the amount of reps you lift for each exercise. Then when you go in to train again the next week, you'll know what you are trying to improve upon. If you find out that you're weaker than you were the time before, and everything else like nutrition, etc. is in line, you may be training too often.

Food and Hydration

Drink at least eight glasses of water a day to keep hydrated. Dehydration can rob you of energy for your workouts. Drink plenty of water while working out. Avoid sugary drinks, since they will cause fatigue after an initial burst of energy. Some people like to drink green tea or creatine supplements in water before a workout to help increase energy levels through a workout.

A light carbohydrate meal (fruits, carbohydrate drinks, etc.) before a workout and a protein-rich one afterwards is advisable. Keep yourself well hydrated with plenty of water throughout the workout. And get plenty of rest afterwards.

Do not work out right after eating a regular meal; wait at least two hours. If you need a snack, have some fruit and a slice of toast with peanut butter one hour or more before working out. Do not consume protein shakes before working out (leave them for after the workout). Digestion will slow down your workouts and bring your energy down. Within 30-60 minutes after the workout, feed your muscles with a balanced meal containing protein, good fats (olive oil, flaxseed oil), and complex carbohydrates, like fruits and whole grains.

Supplements like glutamine, creatine, and whey protein may be a good thing to consider. A shake containing one heaping tablespoon of glutamine, two tablespoons of Omega 3 oils, one or two scoops of whey protein, some fruit, and milk (if you are lactose intolerant try almond or rice milk, though not soy, since it may increase estrogen in both men and women), provides a good balanced meal after a workout.

Home Based Economical Exercise Helpers

I love the following three cheap devices:


1- An exercise (medicine) ball and elastic bands. You can get one at $14 at Target or any retail store. Make sure it comes with its own pump


2-I love the chin-up (pull-up) bars that you can install on door frames.


3- Get yourself a cheap pedometer in any store to make sure you wear it from the moment you wake up until you go to bed. Ensure that you reach close to 10,000 steps a day for best aerobic capacity. I like the Omron-HJ-150-Hip-pedometer available at amazon.com

Exercise Resources

Several exercise routines are provided on our website, www.medibolics.com/exercise.html


Video:Click here

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